Diagnosis of myoepithelioma through light microscopy is possible and immunohistochemistry is done to facilitate the diagnosis. Read myoepithelioma of the parotid gland in a child. The cystic lesion has a mildly fibrotic appearing wall, is lined by histiocytes intermixed with rare lymphocytes, and contains mucous and macrophages. Myoepithelioma is a rare neoplasm in the salivary glands, and was. Report of 23 cases twelve of these were located within the parotid gland and the submandibular gland and intraoral minor salivary glands accounted for five each.
Myoepithelioma is a rare but wellcharacterized group of tumours, among which myoepithelioma of the salivary glands is the best known. The lesions should not be mistaken for metastases, or the result of direct invasion from a primary bladder lesion. Rather, we believe that in general, physicians are simply unaware of its existence. Although occasionally seen in the salivary glands, to our knowledge, this tumor has not previously been described in the lacrimal gland. While myoepithelioma has no specific clinical features, it is accepted pathologically as a distinct entity. Myoepithelioma of a minor salivary gland of the cheek. Only three cases of sinonasal myoepithelioma have been reported in the literature. The me case was a 36yearold female complaining of a painless mass in the.
Sep 24, 2014 soft tissue myoepithelial carcinoma and myoepithelioma are rare entities, part of myoepithelial tumors. Hence, histopathologic examination should be considered to differentiate these tumors. Primary myoepithelial carcinoma of palate world journal. Salivary gland malignant myoepithelioma nagao 1998 cancer. A 54yearold woman was admitted to the hospital complaining exertional dyspnea, cough and intermittent pleuritic chest pain, from which she had been suffering for the last 6 months. Epithelialmyoepithelial carcinoma of parotid glanda. Introduction myoepithelioma is defined as a benign tumour composed of myoepithelial cells. Histological examination of the second recurrence showed a malignant spindle cell.
This atlas provides a comprehensive outline of all but the very rarest salivary gland diseases, detailing the most common benign and malignant tumors with their radiological, cytopathological, and histological features. Pdf myoepithelial cells mecs are considered to be a key participant in most salivary gland. The tumor is composed exclusively of myoepithelial cells that show spindle, plasmacytoid, and clear cell morphology. Subsequently the tumour recurred twice and was characterised by invasion of the mandible. Myoepithelioma of minor salivary glands a diagnostic challenge. Myoepitheliomas are tumors arising from myoepithelial cells mainly or exclusively. Pdf pathophysiology of myoepithelial cells in salivary glands. We herein report an extremely rare case of this tumor with lipomatous. Read myoepithelioma of the parotid gland, pathology international on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. We report two patients with myoepithelioma of parotid gland presenting as infraauricular subcutaneous mass. Oncocytic change in myoepithelial cells in mes and pas can cause pitfalls in the differential diagnosis of salivary gland tumours. The prognosis of the individual depends upon a set of several factors including the tumor stage and overall health of the individual. Capsules are generally better developed in tumors of the major glands, whereas those arising in the palate or other minor salivary or seromucinous gland sites are circumscribed but not usually encapsulated.
Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement membrane and the. Malignant myoepithelioma of salivary gland dovemed. Salivary gland myoepithelioma with focal capsular invasion. Myoepithelial cells of ectodermal origin and mesodermal functionality, normal constituent cells of ductal structures in major and minor salivary glands and other organs, are modified cellular elements with both epithelial and myocontractile properties. As the name suggests, it consists of myoepithelial cells. To the best of our knowledge, such an association has never been reported in the literature.
Plasmacytoid myoepithelioma of minor salivary glands. Myoepitheliomas are most common in young adults between the ages of 30 and 50 and there are very few cases reported in. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary glands of the oral cavity. Myoepitheliomas are rare, benign neoplasms affecting predominantly parotid gland and to a lesser extent minor salivary glands. Jan, 2010 myoepithelioma have been described most commonly in salivary gland and accounts for 1% of all tumors developing in the salivary gland. Myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. Rare benign tumor composed only of myoepithelial cells. Histological examination of the second recurrence showed a malignant spindle cell neoplasm with. Recurrent myoepithelioma treated by palatal and piriform. Please remove adblock adverts are the main source of revenue for dovemed.
The treatment of myoepitheliomas is complete removal of the tumor. Losito nsbotti gionna fpasquinelli gminenna pbisceglia m clearcell myoepithelial carcinoma of the salivary glands. Original research myoepithelioma of the parotid gland. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. Two tumours presented as intraoral lesions and eight were located in the parotid gland.
It can be present in individuals of a wide age range including children and adults. Oncocytic myoepithelioma and pleomorphic adenoma of the. The histological appearance includes solid, myxoid and reticular growth patterns. She had been taken antihypertensive drugs for 10 years. The tumor shows wide morphologic and cytologic diversity in a similar way to its benign counterpart, myoepithelioma, with evidence of malignant change. However, they may be malignant and infiltrate locally. We here report an extremely rare case of myoepithelioma with remarkable cystic formation in the parotid gland in an 80yearold female. They were incorporated into the world health organization classification of soft tissue tumors in 2002. This tumour may be particularly locally aggressive, but its clinical and biological features are not yet fully understood. Myoepithelioma of the tongueclinicopathological and. Myoepithelioma of salivary glands are very rare, accounting for only 1%1. A myoepithelial carcinoma, a rare malignant salivary gland neoplasm, arose in a pleomorphic adenoma of the parotid gland.
Myoepithelioma of the lung european journal of cardio. Myoepitheliomas are a type of pleomorphic adenoma in which. Salivary gland myoepithelial carcinoma springerlink. Salivary gland malignant myoepithelioma american cancer. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland.
Myoepithelioma me and myoepithelial carcinoma mec are both rare salivary neoplasms. Vimentin and s100 protein are very sensitive but nonspecific immunohistochemical markers of neoplastic myoepithelium. Myoepithelioma is a rare benign myoepithelial tumour and its malignant counterpart is myoepithelial carcinoma. They most commonly affect the major and minor salivary glands with the parotid gland being the most common, approximately 40%. Myoepithelioma are uncommon, representing approximately 1% of salivary gland tumors. Nov 18, 2016 myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues.
The study comprised six female and four male patients aged 1463 years mean age 38. Pure accounting for less than 1% of all salivary gland tumors. Dec 01, 2018 the treatment for myoepithelial carcinoma of salivary gland involves a combination of surgery, chemotherapy, and radiation therapy, in most cases. A similar tumor type may be found in the tongue, referred to as ectomesenchymal chondromyxoid tumor.
Myoepithelioma is a benign salivary gland neoplasm, locally invasive and uncommon in children. Three cases were retrieved from the files at the massachusetts general hospital mgh. Combined myoepithelial carcinoma and myoepithelioma in soft. The most common site is parotid gland with a few arising in minor salivary glands of the oral cavity and palate. Who gets myoepithelial carcinoma of salivary gland. Voluminous myoepithelioma of the minor salivary glands. In addition, all six cases of bme in our files also were analyzed comparatively for cell. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign as the name suggests, it consists of myoepithelial cells. One case arose in the minor salivary gland of the soft palate. The diagnosis is rendered histopathologically, and it includes the. Health, general cancer diagnosis research cancer diagnosis carcinoembryonic antigen genetic aspects cea oncology immunohistochemistry intermediate filament proteins medical research medicine, experimental salivary gland tumors tumor proteins. Formerly considered a variant of pleomorphic adenoma. Objective of this study is to highlight the importance of considering clinical and radiological findings in parotid tumors before operating tumors with high suspicion of malignancy though reported as benign on histopathology.
It was once considered to be a type of pleomorphic adenoma pa, but myoepitheliomas are today believed to be relatively aggressive tumors. Myoepithelioma of parotid gland presenting as infraauricular. Health, general cancer diagnosis research cancer diagnosis carcinoembryonic antigen genetic aspects cea oncology immunohistochemistry intermediate filament proteins medical research medicine, experimental salivary gland tumors tumor. Original article, clinical report by ear, nose and throat journal. The vast majority are benign, with only rare malignant examples reported in the literature.
The lesions were clinically suspected to be epidermal cyst. Pdf myoepitheliomas are rare tumours that may generally arise from the minor or major salivary glands. Myoepithelioma is a rare tumor, accounting for less than 1. The sections show a stratified squamous epithelium with a thin layer of parakeratosis, minor salivary glands, and a wellcircumscribed cystic lesion. Myoepithelioma is a benign salivary gland tumor in the head and neck region, accounting for 11. Myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. In this report, we describe two cases of a benign myoepithelioma of the parotid gland. Myoepithelioma of minor salivary glands a diagnostic. Only a few case reports describing ct imaging features of me have been published.
Salivary gland myoepithelial carcinoma mc or malignant myoepithelioma is a rare entity. Myoepitheliomas mostly occur in salivary glands, as well as in breast, skin, and lung. Here we present an exceptional case of myoepithelial carcinoma and myoepithelioma association. She had a retroauricular subcutaneous mass with an underlying diagnosis of a cutaneous myoepithelioma, which was excised at a hospitals dermatology department 2 years earlier. Myoepithelioma me is a benign salivary gland tumor composed almost exclusively of sheets, islands, or cords of cells with myoepitheliomal differentiation. Mc usually presents as a slowgrowing painless mass arising in the parotid gland, but may involve other salivary glands. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign. Myoepitheliomas mes are rare tumors of the parotid gland.
The aim of this study is to present and discuss the clinical, morphological and immunohistochemical. Generally, this tumor exhibits painless solid mass. Myoepitheliomas of minor salivary glands accounts to only 1. Eleven months after the completion of the radiotherapy treatment the patient died as a result of undercurrent heart disease, without any. We are reporting a case of recurrent myoepithelioma of the parotid gland, that emerged as a cutaneous mass. Myoepithelial cell, neoplasm, salivary gland tumor. We selected 4 cases of small salivary gland myoepitheliomas from the files of the pathology lab of the oral pathology department of the federal university of.
Myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. These tumors can occur in most of the glandular structures like salivary glands, breast and sweat glands of the skin. Myoepithelioma of the parotid gland, pathology international. The aim of this study was to describe and characterize the ct findings of mes of the parotid. Mar 18, 2015 myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. The diagnosis is rendered histopathologically, and it includes the proliferation of myoepithelial cells, without chondroid or myxochondroid stroma and ductal components up to 5% of ductal component is acceptable. Myoepithelioma of the parotid gland presenting as a. The documents used were obtained via a bibliographical search. Treatment should be designed as for a benign salivary gland tumor with a margin of normal uninvolved tissue being included within the surgical excision. Myoepithelioma of parotid gland presenting as infra. Myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. Myoepithelial carcinoma malignant myoepithelioma of the. Salivary gland diseases sgd are multiple and varied in cause there are three paired major salivary glands in humans the parotid glands, the submandibular glands, and the sublingual glands, and about 800 minor salivary glands in the mucosa of the mouth.
Malignant myoepithelioma of the salivary gland is discussed in terms of its clinical behaviour, morphological features and the frequent preexistence of a pleomorphic adenoma. Myoepithelioma is a relatively rare form of salivary gland tumor, accounting for less than 1% of all salivary gland neoplasms. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral. Myoepithelioma and related lesions pocket dentistry. Learn indepth information on malignant myoepithelioma of salivary gland, its causes, symptoms, diagnosis, complications, treatment, prevention, and prognosis. Dec 12, 2011 myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. It is normally located in the major salivary glands.
Myoepithelioma is a rare, benign salivary neoplasm, most frequently located in the salivary gland. Mar 27, 2018 myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. Only 1% of all salivary gland neoplasms are myoepitheliomas. Myoepithelial carcinoma malignant myoepithelioma is a rare salivary gland tumor composed entirely of myoepithelial cells that exhibit a dual epithelial and smooth muscle phenotype. Classically, they are found in the parotid gland or palate.
Since 1943 when sheldon identified them and characterized them as myoepithelioma, less than 100 cases have been reported in the literature. Pdf myoepithelioma, a benign tumor, occurs with a frequency of 1. Jul 11, 2008 myoepithelioma is a rare benign neoplasm. The parotid gland is located in front of the ear, and it secretes its mostly serous saliva via the parotid duct stenson duct.
We present a case of recurrent myoepithelioma in the nasal cavity with a palatal fistula treated both by a palatal approach and a piriform apertural approach. Parotid gland myoepithelioma with remarkable cystic. The recurrence rate is similar to that of the pleomorphic adenoma 1518%. We describe some unusual histological features associated with onococytic metaplasia in benign myoepithelial cellderived salivary gland tumours, hoping to help to avoid the overdiagnosis of malignancy.
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